{"product_id":"tsp1-antibody-sc-f1912","title":"Thrombospondin 1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTSP1 is a large extracellular matrix glycoprotein forming a homotrimer via disulfide bonds, with each monomer containing distinct domains such as an N-terminal heparin-binding domain, procollagen-like domain, type 1 repeats (TSRs), type 2 EGF-like repeats, type 3 calcium-binding repeats, and a C-terminal globular domain. These domains facilitate interactions with cell surface receptors, including CD36, CD47, integrins, and extracellular matrix components, mediating diverse biological functions. Depending on the literature source, TSP1 may also be discussed as Thrombospondin 1 and Glycoprotein G.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endoplasmic reticulum, extracellular matrix, sarcoplasmic reticulum, and secreted, which can matter when signal is compared across treatments or changing cell states. Following TSP1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTSP1 is commonly interpreted in the context of cancer, immunology, and cardiovascular research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endoplasmic reticulum, extracellular matrix, and sarcoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between endoplasmic reticulum, extracellular matrix, and sarcoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TSP1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TSP1 reflect biology rather than handling. When interpreting TSP1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TSP1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577832153433,"sku":"F1912-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577832186201,"sku":"F1912-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577832218969,"sku":"F1912-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1912-IF.png?v=1773600077","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tsp1-antibody-sc-f1912","provider":"Absource Diagnostics","version":"1.0","type":"link"}