{"product_id":"tsg101-antibody-sc-f1543","title":"TSG101 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTSG101 (Tumor Susceptibility Gene 101) encodes a highly conserved, ubiquitously expressed multidomain protein that plays essential roles in cell proliferation, survival, and intracellular protein trafficking. Structurally, TSG101 contains a ubiquitin-conjugating enzyme E2 variant (UEV) domain that binds ubiquitin and PTAP motifs but lacks enzymatic activity, a proline-rich domain (PRD), a coiled-coil domain (CC), and a C-terminal steadiness box (SB) responsible for autoregulating protein levels. Depending on the literature source, TSG101 may also be discussed as Tumor susceptibility gene 101 protein and ESCRT-I complex subunit TSG101.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoskeleton, endosome, and membrane, which can matter when signal is compared across treatments or changing cell states. Following TSG101 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTSG101 is commonly interpreted in the context of cancer and cell cycle research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and endosome, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoskeleton, and endosome across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TSG101. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TSG101 reflect biology rather than handling. When interpreting TSG101, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TSG101 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577771729241,"sku":"F1543-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577771762009,"sku":"F1543-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577771794777,"sku":"F1543-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1543-IF.png?v=1773599854","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tsg101-antibody-sc-f1543","provider":"Absource Diagnostics","version":"1.0","type":"link"}