{"product_id":"tpd52-antibody-sc-f3324","title":"TPD52 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTPD52 (Tumor Protein D52) is a proto-oncogene frequently overexpressed in multiple malignancies, including prostate, breast, ovarian, and colorectal cancers, primarily due to gene amplification at the chromosomal locus 8q21. Structurally, TPD52 is a 184-amino acid, hydrophilic protein featuring conserved N- and C-terminal PEST domains-typically linked to protein turnover-alongside a coiled-coil motif critical for protein-protein interactions and a D2 motif essential for functional binding. Depending on the literature source, TPD52 may also be discussed as Tumor protein D52 and Protein N8.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and endoplasmic reticulum, which can matter when signal is compared across treatments or changing cell states. Following TPD52 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTPD52 is commonly interpreted in the context of cancer and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TPD52. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TPD52 reflect biology rather than handling. When interpreting TPD52, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TPD52 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578015064409,"sku":"F3324-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578015097177,"sku":"F3324-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578015129945,"sku":"F3324-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3324-IF.png?v=1773601113","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tpd52-antibody-sc-f3324","provider":"Absource Diagnostics","version":"1.0","type":"link"}