{"product_id":"tnfaip3-antibody-sc-f0369","title":"A20\/TNFAIP3 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eA20 is a zinc finger protein which has been characterized as a dual inhibitor of NF-kappa B activation and apoptosis. It is also referred to as TNF-α-induced protein 3 (TNFAIP3), is cytokine-inducible protein. A20 has been shown to interact via its N-terminal domain with TRAF1 and TRAF2, which are part of the NF-κB activation cascade initiated by TNF as well as with TRAF6, which is part of the IL-1- and LPS-induced signaling pathway to NF-κB. Depending on the literature source, TNFAIP3 may also be discussed as A20\/TNFAIP3.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, lysosome, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following TNFAIP3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTNFAIP3 is commonly interpreted in the context of inflammation research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, lysosome, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, lysosome, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TNFAIP3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TNFAIP3 reflect biology rather than handling. When interpreting TNFAIP3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TNFAIP3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577447620953,"sku":"F0369-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577447653721,"sku":"F0369-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577447686489,"sku":"F0369-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0369-wb.gif?v=1773598385","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tnfaip3-antibody-sc-f0369","provider":"Absource Diagnostics","version":"1.0","type":"link"}