{"product_id":"thalidomide-o-cooh-cereblon-ligand-3-s6794","title":"Thalidomide-O-COOH (Cereblon ligand 3)","description":"\u003cp\u003e\u003cstrong\u003eThalidomide-O-COOH (Cereblon ligand 3)\u003c\/strong\u003e is a ligand of E3 Ligase used in studies of Protein Degradation \/ Proteasome. It is especially relevant in cancer and protein homeostasis models, where defined compound exposure can be linked to ubiquitin-dependent turnover, proteostasis, and targeted protein degradation.\u003c\/p\u003e\n\n\u003cp\u003eBy engaging E3 Ligase, Thalidomide-O-COOH (Cereblon ligand 3) can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving E3 Ligase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Protein Degradation \/ Proteasome\u003c\/li\u003e\n\u003cli\u003eLigand-binding and signaling assays\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Thalidomide-O-COOH (Cereblon ligand 3) is appropriate when a defined chemical perturbant is needed to connect E3 Ligase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809425498457,"sku":"S6794-5MG","price":95.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809425531225,"sku":"S6794-25MG","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/thalidomide-o-cooh-chemical-structure-s6794.gif?v=1776200480","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/thalidomide-o-cooh-cereblon-ligand-3-s6794","provider":"Absource Diagnostics","version":"1.0","type":"link"}