{"product_id":"tgfbr2-antibody-sc-f2400","title":"TGF β Receptor II Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTGFBR2 is a target of interest in many antibody-based workflows. The TGF β Receptor II, (transforming growth factor-β type II receptor, TβRII) is a type I transmembrane glycoprotein and a constitutively active serine\/threonine kinase that initiates TGF-β signaling. It comprises an extracellular ligand-binding ectodomain with a three-finger toxin fold stabilized by six disulfide bonds (four conserved among type II receptors and two unique to TβRII), a single transmembrane segment, and an intracellular kinase domain. Depending on the literature source, TGFBR2 may also be discussed as TGF beta Receptor II and TGF-beta receptor type-2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, membrane, and secreted, which can matter when signal is compared across treatments or changing cell states. Following TGFBR2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTGFBR2 is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, membrane, and secreted, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, membrane, and secreted across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TGFBR2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TGFBR2 reflect biology rather than handling. When interpreting TGFBR2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TGFBR2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577933996377,"sku":"F2400-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577934029145,"sku":"F2400-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577934061913,"sku":"F2400-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2400-IHC1.jpg?v=1773600368","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tgfbr2-antibody-sc-f2400","provider":"Absource Diagnostics","version":"1.0","type":"link"}