{"product_id":"tezacaftor-vx-661-s7059","title":"Tezacaftor (VX-661)","description":"\u003cp\u003e\u003cstrong\u003eTezacaftor (VX-661)\u003c\/strong\u003e is a modulator of CFTR used in studies of ion-channel pharmacology. In practice, this places the compound in experiments that measure ion conductance, membrane potential, and electrophysiological responses in cell signaling models. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating CFTR, Tezacaftor (VX-661) can be used to examine ion conductance, membrane potential, and electrophysiological responses. This target class is commonly examined through electrophysiology, ion-flux, and membrane-potential studies, together with downstream-response mapping. In cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CFTR\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eElectrophysiology, ion-flux, and membrane-potential studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cell signaling models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Tezacaftor (VX-661) is appropriate when a defined chemical perturbant is needed to connect CFTR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809450205529,"sku":"S7059-5MG","price":265.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809450238297,"sku":"S7059-50MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809450271065,"sku":"S7059-1G","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809450303833,"sku":"S7059-1ML\/DMSO","price":488.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/VX661-chemical-structure-s7059.gif?v=1776200865","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tezacaftor-vx-661-s7059","provider":"Absource Diagnostics","version":"1.0","type":"link"}