{"product_id":"tcs-pim-1-1-s1050","title":"TCS PIM-1 1","description":"\u003cp\u003e\u003cstrong\u003eTCS PIM-1 1\u003c\/strong\u003e is an inhibitor of PIM used in studies of JAK-STAT Signaling and Cell Cycle Regulation. It is especially relevant in cancer and cell signaling models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PIM, TCS PIM-1 1 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PIM\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and Cell Cycle Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, TCS PIM-1 1 is appropriate when a defined chemical perturbant is needed to connect PIM with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805190594905,"sku":"S1050-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805190627673,"sku":"S1050-25MG","price":363.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/tcs-pim-1-1-chemical-structure-s1050.gif?v=1776172816","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tcs-pim-1-1-s1050","provider":"Absource Diagnostics","version":"1.0","type":"link"}