{"product_id":"tau-antibody-sc-f2593","title":"Phospho-Tau (Ser404) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePhospho-Tau (Ser404) refers to tau protein phosphorylated at serine residue 404, a modification linked to neurodegenerative diseases, particularly Alzheimer's disease. Tau stabilizes axonal microtubules and has six isoforms that differ by the number of microtubule-binding repeats. Phosphorylation at Ser404, catalyzed by kinases such as GSK3β and Cdk5, reduces tau's microtubule-binding affinity, leading to destabilization and promoting aggregation. Depending on the literature source, TAU may also be discussed as Phospho-Tau (Ser404).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, cytoplasm, and cytoskeleton, which can matter when signal is compared across treatments or changing cell states. Following TAU across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTAU is commonly interpreted in the context of neuroscience research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TAU. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TAU reflect biology rather than handling. When interpreting TAU, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TAU trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577962439001,"sku":"F2593-20UL","price":159.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577962471769,"sku":"F2593-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577962504537,"sku":"F2593-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/f2593-IHC1.jpg?v=1773600562","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tau-antibody-sc-f2593","provider":"Absource Diagnostics","version":"1.0","type":"link"}