{"product_id":"stk3-stk4-antibody-sc-f0855","title":"Phospho-MST1\/2 (Thr183\/180) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePhospho-MST1\/2 (Thr183\/180) is a target of interest in many antibody-based workflows. MST1 (STK4) and MST2 (STK3) are closely related serine\/threonine kinases that belong to the GCK-II subfamily of kinases. Structurally, they share a conserved kinase domain and a C-terminal SARAH domain, which facilitates homo- and heterodimerization with other SARAH-containing proteins like RASSF1-6 and Sav1\/WW45. MST1 consists of 487 amino acids, and MST2 has 491. Depending on the literature source, Phospho-MST1\/2 (Thr183\/180) may also be discussed as Phospho-MST1\/2 (Thr183\/180) and MST1\/MST2 (phospho T180 + T183).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoskeleton, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following Phospho-MST1\/2 (Thr183\/180) across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state. In practice, this target is often considered at the family or isoform-group level, so experimental interpretation benefits from matched controls and clear comparison logic.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePhospho-MST1\/2 (Thr183\/180) is commonly interpreted in the context of developmental biology and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoskeleton, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for Phospho-MST1\/2 (Thr183\/180). This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in Phospho-MST1\/2 (Thr183\/180) reflect biology rather than handling. When interpreting Phospho-MST1\/2 (Thr183\/180), it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep Phospho-MST1\/2 (Thr183\/180) trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577533473113,"sku":"F0855-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577533505881,"sku":"F0855-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577533538649,"sku":"F0855-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0855-wb.gif?v=1773599015","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/stk3-stk4-antibody-sc-f0855","provider":"Absource Diagnostics","version":"1.0","type":"link"}