{"product_id":"stk11-antibody-sc-f0235","title":"LKB1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eLKB1 (STK11) is a type of protein known as a serine\/threonine kinase and serves as a crucial tumor suppressor. It plays a significant role in regulating cell structure, apoptosis (cell death), and maintaining energy balance within cells by controlling various downstream kinases. Initially identified as the gene responsible for Peutz-Jeghers syndrome (PJS), a condition characterized by the presence of hamartomatous polyps and distinctive pigmentation of the oral mucosa, LKB1 has since been implicated in a range of malignancies, including lung, gastrointestinal, pancreatic, and breast cancers. Depending on the literature source, STK11 may also be discussed as LKB1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, membrane, mitochondrion, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following STK11 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSTK11 is commonly interpreted in the context of cancer, metabolism, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, membrane, and mitochondrion, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, membrane, and mitochondrion across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for STK11. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in STK11 reflect biology rather than handling. When interpreting STK11, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep STK11 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577433760089,"sku":"F0235-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577433792857,"sku":"F0235-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577433825625,"sku":"F0235-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0235-IHC1.jpg?v=1773598226","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/stk11-antibody-sc-f0235","provider":"Absource Diagnostics","version":"1.0","type":"link"}