{"product_id":"stenoparib-e7449-s8419","title":"Stenoparib (E7449)","description":"\u003cp\u003e\u003cstrong\u003eStenoparib (E7449)\u003c\/strong\u003e is an inhibitor of PARP and PARP1 and related targets used in studies of Wnt Signaling and DNA Damage Response. In practice, this places the compound in experiments that measure beta-catenin-dependent transcription and developmental signaling and checkpoint activation, DNA repair, and genome-stability control in cancer, developmental biology, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PARP and PARP1 and related targets, Stenoparib (E7449) can be used to examine beta-catenin-dependent transcription and developmental signaling and checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, developmental biology, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PARP and PARP1 and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Wnt Signaling and DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Stenoparib (E7449) is appropriate when a defined chemical perturbant is needed to connect PARP and PARP1 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, developmental biology, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809608704345,"sku":"S8419-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809608737113,"sku":"S8419-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809608769881,"sku":"S8419-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809608802649,"sku":"S8419-1G","price":2938.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e7449-chemical-structure-S8419.gif?v=1776202702","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/stenoparib-e7449-s8419","provider":"Absource Diagnostics","version":"1.0","type":"link"}