{"product_id":"sqstm1-antibody-sc-f2531","title":"SQSTM1\/p62 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ep62, also known as SQSTM1, is a multifunctional scaffolding protein that plays a crucial role in maintaining cellular homeostasis through its involvement in autophagy, protein quality control, and stress responses. Structurally, p62 contains a ubiquitin-associated (UBA) domain that binds to ubiquitinated proteins, an LC3-interacting region (LIR) that facilitates the recruitment of p62 to autophagosomes for cargo degradation, and a Keap1-interacting region (KIR) that regulates oxidative stress via the Nrf2 signalling pathway. Depending on the literature source, SQSTM1 may also be discussed as SQSTM1\/p62 and p62 (Sequestosome-1).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, and endosome, which can matter when signal is compared across treatments or changing cell states. Following SQSTM1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSQSTM1 is commonly interpreted in the context of inflammation, metabolism, and autophagy research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003einterpretation alongside flux, cargo handling, or lysosomal context\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for SQSTM1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in SQSTM1 reflect biology rather than handling. When interpreting SQSTM1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep SQSTM1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577957884249,"sku":"F2531-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577957917017,"sku":"F2531-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577957949785,"sku":"F2531-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2531-IF.png?v=1773600511","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/sqstm1-antibody-sc-f2531","provider":"Absource Diagnostics","version":"1.0","type":"link"}