{"product_id":"smurf1-in-a01-s0345","title":"Smurf1-IN-A01","description":"\u003cp\u003e\u003cstrong\u003eSmurf1-IN-A01\u003c\/strong\u003e is an inhibitor of E3 Ligase used in studies of TGF-beta \/ Smad Signaling and Protein Degradation \/ Proteasome. In practice, this places the compound in experiments that measure Smad-mediated transcription, differentiation, and fibrotic signaling and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in cancer, developmental biology, and protein homeostasis models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting E3 Ligase, Smurf1-IN-A01 can be used to examine Smad-mediated transcription, differentiation, and fibrotic signaling and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, developmental biology, and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving E3 Ligase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to TGF-beta \/ Smad Signaling and Protein Degradation \/ Proteasome\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Smurf1-IN-A01 is appropriate when a defined chemical perturbant is needed to connect E3 Ligase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, developmental biology, and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805099401561,"sku":"S0345-5MG","price":154.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805099434329,"sku":"S0345-25MG","price":461.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s0345-smurf1-in-a01-chemical-structure.gif?v=1776172105","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/smurf1-in-a01-s0345","provider":"Absource Diagnostics","version":"1.0","type":"link"}