{"product_id":"smoothened-smo-or-frizzled-11-or-fzd11-antibody","title":"Smoothened (SMO or Frizzled-11 or FZD11) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\n\u003cp\u003eThis antibody enables you to investigate Smoothened with a direct, biology-first readout. Smoothened is a pathway component whose activation state and localization can change after stimulation. Look for shifts in distribution that track with phenotype changes.\u003c\/p\u003e\n\u003cp\u003eIn some datasets and protocols, it is referenced by the gene symbol FZD11.\u003c\/p\u003e\n\u003ch2\u003eResearch Context\u003c\/h2\u003e\n\u003cp\u003eParallel measurement of upstream inputs and downstream readouts can sharpen interpretation of pathway behavior. Pair measurements with orthogonal readouts when interpretation is sensitive to context. Planar polarity studies may connect this target to directional signaling and cytoskeletal alignment.\u003c\/p\u003e\n\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003econdition-to-condition comparisons with matched controls\u003c\/li\u003e\n\u003cli\u003etime-resolved changes following stimulation or inhibition\u003c\/li\u003e\n\u003cli\u003einteraction patterns within multi-protein complexes\u003c\/li\u003e\n\u003cli\u003elocalization shifts between cytoplasm, membrane, and nucleus\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\n\u003cp\u003eFor broad method development, the regular format can help you benchmark target behavior before narrowing to a specific readout style. This matters because epitope exposure and background can vary with preparation and extraction steps. If you compare conditions, keep processing steps uniform to support clean interpretation.\u003c\/p\u003e\n\u003cp\u003eFor challenging targets, pairing Smoothened measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.\u003c\/p\u003e\n\u003cp\u003eFor challenging targets, pairing Smoothened measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.\u003c\/p\u003e\n\u003cp\u003eWith a clear focus on Smoothened, this regular format option fits streamlined studies and fast iteration.\u003c\/p\u003e","brand":"BiCell Scientific","offers":[{"title":"50 µl \/ No Blocker","offer_id":58101641314649,"sku":"50611-50UL","price":305.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 1 µg","offer_id":58101641347417,"sku":"50611-50UL+1UG","price":374.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 10 µg","offer_id":58101641380185,"sku":"50611-50UL+10UG","price":424.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ No Blocker","offer_id":58101641412953,"sku":"50611-200UL","price":635.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 1 µg","offer_id":58101641445721,"sku":"50611-200UL+1UG","price":704.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 10 µg","offer_id":58101641478489,"sku":"50611-200UL+10UG","price":754.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/smo-retina-pfa-0.5-5min_b2267710-249c-4741-9424-09c124c025e2.jpg?v=1779280839","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/smoothened-smo-or-frizzled-11-or-fzd11-antibody","provider":"Absource Diagnostics","version":"1.0","type":"link"}