{"product_id":"smarcb1-baf47-antibody-sc-f1264","title":"SMARCB1\/BAF47 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eSMARCB1\/BAF47 is a target of interest in many antibody-based workflows. SMARCB1, also known as SNF5, BAF47, is a crucial member of the SWI\/SNF (SWItch\/Sucrose Non-Fermentable) chromatin-remodeling multiprotein complex. This ubiquitously expressed nuclear protein, encoded by the SMARCB1 gene on chromosome 22 (22q11. 23), is involved in recruiting the SWI\/SNF complex to the core promoter of rRNA genes via its interaction with PIH1 domain-containing protein 1 (PIH1) and histone H4, thus regulating chromatin remodelling. Depending on the literature source, SMARCB1\/BAF47 may also be discussed as SMARCB1\/BAF47 and BAF47.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following SMARCB1\/BAF47 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSMARCB1\/BAF47 is commonly interpreted in the context of cancer and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within nucleus relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for SMARCB1\/BAF47. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in SMARCB1\/BAF47 reflect biology rather than handling. When interpreting SMARCB1\/BAF47, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep SMARCB1\/BAF47 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577674867033,"sku":"F1264-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577674899801,"sku":"F1264-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577674932569,"sku":"F1264-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1264-IHC1.jpg?v=1773599512","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/smarcb1-baf47-antibody-sc-f1264","provider":"Absource Diagnostics","version":"1.0","type":"link"}