{"product_id":"sklb-197-e1136","title":"SKLB-197","description":"\u003cp\u003e\u003cstrong\u003eSKLB-197\u003c\/strong\u003e is an inhibitor of ATR and ATM used in studies of DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ATR and ATM, SKLB-197 can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ATR and ATM\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SKLB-197 is appropriate when a defined chemical perturbant is needed to connect ATR and ATM with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804331254105,"sku":"E1136-5MG","price":265.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804331286873,"sku":"E1136-25MG","price":795.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804331319641,"sku":"E1136-100MG","price":1936.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e1136-sklb-197-chemical-structure.gif?v=1776166534","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/sklb-197-e1136","provider":"Absource Diagnostics","version":"1.0","type":"link"}