{"product_id":"sirt1-antibody-sc-f0526","title":"SIRT1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eSirt1, a mammalian member of the sirtuin family, functions as a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase, targeting both histone and nonhistone proteins. It plays a crucial role in regulating energy homeostasis in response to nutrient availability. Specifically, hepatic Sirt1 regulates lipid homeostasis by positively modulating peroxisome proliferators-activated receptor α (PPARα), a nuclear receptor involved in the adaptive response to fasting and starvation. Depending on the literature source, SIRT1 may also be discussed as Sir2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, cytoplasm, and mitochondrion, which can matter when signal is compared across treatments or changing cell states. Following SIRT1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSIRT1 is commonly interpreted in the context of metabolism and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, cytoplasm, and mitochondrion, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between nucleus, cytoplasm, and mitochondrion across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for SIRT1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in SIRT1 reflect biology rather than handling. When interpreting SIRT1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep SIRT1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577467412825,"sku":"F0526-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577467445593,"sku":"F0526-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577467478361,"sku":"F0526-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0526-IHC1.jpg?v=1773598580","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/sirt1-antibody-sc-f0526","provider":"Absource Diagnostics","version":"1.0","type":"link"}