{"product_id":"ship1-antibody-sc-f1428","title":"SHIP1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eSHIP1 (Inositol polyphosphate 5-phosphatase D) plays a vital role in immune cell signaling by regulating phosphoinositide metabolism. It primarily acts by hydrolyzing PI(3,4,5)P3 to produce PI(3,4)P2, thereby influencing the recruitment of downstream effector proteins that interact with these phosphoinositides, such as Btk and Vav. By lowering PI(3,4,5)P3 levels, SHIP1 inhibits essential pathways involved in cell activation and migration, including Ca²⁺ signaling, MAPK, and NFκB pathways.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, cytoskeleton, and membrane, which can matter when signal is compared across treatments or changing cell states. Following SHIP1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eSHIP1 is commonly interpreted in the context of inflammation and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and cytoskeleton, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and cytoskeleton across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for SHIP1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in SHIP1 reflect biology rather than handling. When interpreting SHIP1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep SHIP1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577736012121,"sku":"F1428-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577736044889,"sku":"F1428-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577736077657,"sku":"F1428-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1428-IF.png?v=1773599737","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ship1-antibody-sc-f1428","provider":"Absource Diagnostics","version":"1.0","type":"link"}