{"product_id":"sgi-1776-free-base-s2198","title":"SGI-1776 free base","description":"\u003cp\u003e\u003cstrong\u003eSGI-1776 free base\u003c\/strong\u003e is an inhibitor of PIM and FLT3 used in studies of MAPK \/ ERK Signaling and JAK-STAT Signaling and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PIM and FLT3, SGI-1776 free base can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PIM and FLT3\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and JAK-STAT Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SGI-1776 free base is appropriate when a defined chemical perturbant is needed to connect PIM and FLT3 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805459784025,"sku":"S2198-5MG","price":137.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805459816793,"sku":"S2198-10MG","price":265.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805459849561,"sku":"S2198-50MG","price":658.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805459882329,"sku":"S2198-1G","price":3921.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805459915097,"sku":"S2198-1ML\/DMSO","price":220.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/SGI-1776-chemical-structure-S2198.gif?v=1776174630","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/sgi-1776-free-base-s2198","provider":"Absource Diagnostics","version":"1.0","type":"link"}