{"product_id":"rosiglitazone-brl-49653-s2556","title":"Rosiglitazone (BRL 49653)","description":"\u003cp\u003e\u003cstrong\u003eRosiglitazone (BRL 49653)\u003c\/strong\u003e is an agonist of PPAR and PPAR gamma used in studies of Autophagy and Calcium Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to autophagic flux, lysosomal turnover, and stress adaptation and calcium flux, excitability, and secretion-linked signaling in autophagy, endocrinology, and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating PPAR and PPAR gamma, Rosiglitazone (BRL 49653) can be used to examine autophagic flux, lysosomal turnover, and stress adaptation and calcium flux, excitability, and secretion-linked signaling. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In autophagy, endocrinology, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PPAR and PPAR gamma\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Autophagy and Calcium Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eAgonist-response and downstream signaling studies\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Rosiglitazone (BRL 49653) is appropriate when a defined chemical perturbant is needed to connect PPAR and PPAR gamma with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, endocrinology, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57805668614489,"sku":"S2556-25MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805668647257,"sku":"S2556-50MG","price":216.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805668680025,"sku":"S2556-200MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805668712793,"sku":"S2556-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"5 g","offer_id":57805668745561,"sku":"S2556-5G","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805668778329,"sku":"S2556-1ML\/DMSO","price":186.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Rosiglitazone-Avandia-chemical-structure-S2556.gif?v=1776175260","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/rosiglitazone-brl-49653-s2556","provider":"Absource Diagnostics","version":"1.0","type":"link"}