{"product_id":"r243-s3479","title":"R243","description":"\u003cp\u003e\u003cstrong\u003eR243\u003c\/strong\u003e is an inhibitor of CCR used in studies of Immune Signaling and GPCR Signaling. It is especially relevant in immunology and inflammation models, where defined compound exposure can be linked to cytokine-mediated signaling and inflammatory effector responses and receptor-driven second-messenger signaling and desensitization dynamics.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting CCR, R243 can be used to examine cytokine-mediated signaling and inflammatory effector responses and receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CCR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Immune Signaling and GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, R243 is appropriate when a defined chemical perturbant is needed to connect CCR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57808898294105,"sku":"S3479-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57808898326873,"sku":"S3479-25MG","price":383.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s3479-r243-chemical-structure.gif?v=1776194969","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/r243-s3479","provider":"Absource Diagnostics","version":"1.0","type":"link"}