{"product_id":"ptgs2-antibody-sc-f2870","title":"COX2 \/ Cyclooxygenase 2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCOX2 \/ Cyclooxygenase 2, encoded by PTGS2, is a potent inducible enzyme that catalyzes the conversion of arachidonic acid (AA) to prostanoids, including prostaglandin Esub\u0026gt;2 (PGEsub\u0026gt;2), a key mediator of inflammation, angiogenesis, and cancer progression. Structurally, COX-2 functions as a homodimer, comprising an EGF-like domain (protein interactions), a membrane-binding domain (ER\/nuclear envelope anchoring), and a catalytic domain (cyclooxygenase and peroxidase activities). Depending on the literature source, PTGS2 may also be discussed as COX2 \/ Cyclooxygenase 2 and Prostaglandin G\/H synthase 2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endoplasmic reticulum, membrane, microsome, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following PTGS2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePTGS2 is commonly interpreted in the context of cancer, immunology, and inflammation research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endoplasmic reticulum, membrane, and microsome, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between endoplasmic reticulum, membrane, and microsome across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PTGS2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PTGS2 reflect biology rather than handling. When interpreting PTGS2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PTGS2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577977282905,"sku":"F2870-20UL","price":159.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577977315673,"sku":"F2870-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577977348441,"sku":"F2870-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2870-IF.png?v=1773600767","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ptgs2-antibody-sc-f2870","provider":"Absource Diagnostics","version":"1.0","type":"link"}