{"product_id":"proguanil-hcl-atovaquone-s3082","title":"Proguanil HCl (Atovaquone)","description":"\u003cp\u003e\u003cstrong\u003eProguanil HCl (Atovaquone)\u003c\/strong\u003e is an inhibitor of DHFR used in studies of DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control in cancer, dna damage \/ repair, and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DHFR, Proguanil HCl (Atovaquone) can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage \/ repair, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DHFR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Proguanil HCl (Atovaquone) is appropriate when a defined chemical perturbant is needed to connect DHFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage \/ repair, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57808651813209,"sku":"S3082-10MG","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/S3082-Proguanil-HCl-Atovaquone-chemical-structure.png?v=1776194425","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/proguanil-hcl-atovaquone-s3082","provider":"Absource Diagnostics","version":"1.0","type":"link"}