{"product_id":"prkaca-antibody-sc-f0588","title":"PKA C-α Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePKA C-α (catalytic subunit alpha of protein kinase A) is a key enzyme in the cAMP-dependent signalling pathway, playing a central role in regulating cellular processes such as metabolism, gene expression, and cell division. Encoded by the PRKACA gene on chromosome 19, PKA C-α is one of three catalytic isoforms (C-α, C-β, and C-γ) and is the most widely expressed across tissues. Depending on the literature source, PRKACA may also be discussed as PKA C-alpha and cAMP Protein Kinase Catalytic subunit.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, cilium, and cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following PRKACA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePRKACA is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and cilium, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and cilium across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PRKACA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PRKACA reflect biology rather than handling. When interpreting PRKACA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PRKACA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577482551641,"sku":"F0588-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577482584409,"sku":"F0588-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577482617177,"sku":"F0588-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0588-wb.gif?v=1773598664","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/prkaca-antibody-sc-f0588","provider":"Absource Diagnostics","version":"1.0","type":"link"}