{"product_id":"presenilin-1-psen1-or-ps1-or-ad3-antibody-ffpe-validated","title":"Presenilin-1 (PSEN1 or PS1 or AD3) Antibody - FFPE Validated","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\n\u003cp\u003ePlan your comparisons around Presenilin-1 and use this antibody to analyze state-dependent differences. Presenilin-1 is a pathway component whose activation state and localization can change after stimulation. Plan positive and negative controls that match your model system, including perturbations expected to shift the target.\u003c\/p\u003e\n\u003cp\u003eIn some datasets and protocols, it is referenced by the gene symbol PS1.\u003c\/p\u003e\n\u003ch2\u003eResearch Context\u003c\/h2\u003e\n\u003cp\u003eWhen comparing conditions, consistent sample handling and normalization are key for meaningful contrasts. Time course design can be decisive when regulation is transient or compartment dependent.\u003c\/p\u003e\n\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003einteraction patterns within multi-protein complexes\u003c\/li\u003e\n\u003cli\u003elocalization shifts between cytoplasm, membrane, and nucleus\u003c\/li\u003e\n\u003cli\u003econdition-to-condition comparisons with matched controls\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\n\u003cp\u003eThis fixed-section oriented version is intended for paraffin-embedded tissue, where crosslinking and retrieval steps can shape epitope accessibility. This matters because epitope exposure and background can vary with preparation and extraction steps. Include controls that separate true target shifts from matrix or preparation effects.\u003c\/p\u003e\n\u003cp\u003eIf your study spans multiple model systems, it can help to define a shared reference condition for Presenilin-1 so cross-sample contrasts stay meaningful.\u003c\/p\u003e\n\u003cp\u003eFor challenging targets, pairing Presenilin-1 measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.\u003c\/p\u003e\n\u003cp\u003eThe fixed-section format fits designs where Presenilin-1 is evaluated with deliberate controls and careful comparisons.\u003c\/p\u003e","brand":"BiCell Scientific","offers":[{"title":"50 µl \/ No Blocker","offer_id":58101556379993,"sku":"51471-FFPE-50UL","price":500.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 1 µg","offer_id":58101556412761,"sku":"51471-FFPE-50UL+1UG","price":569.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 10 µg","offer_id":58101556445529,"sku":"51471-FFPE-50UL+10UG","price":619.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ No Blocker","offer_id":58101556478297,"sku":"51471-FFPE-200UL","price":1110.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 1 µg","offer_id":58101556511065,"sku":"51471-FFPE-200UL+1UG","price":1179.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 10 µg","offer_id":58101556543833,"sku":"51471-FFPE-200UL+10UG","price":1229.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/psen1brain_6af48929-7ec6-4040-b570-8bb177dcb916.jpg?v=1779280372","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/presenilin-1-psen1-or-ps1-or-ad3-antibody-ffpe-validated","provider":"Absource Diagnostics","version":"1.0","type":"link"}