{"product_id":"ppib-antibody-sc-f3009","title":"Cyclophilin B Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePPIB is a target of interest in many antibody-based workflows. Cyclophilin B is an immunophilin that binds cyclosporin A (CsA) and possesses peptidyl-prolyl isomerase (PPIase) activity. It has a conserved β-barrel core fold similar to Cyclophilin A, but with unique loop regions and a critical Trp128 residue that enhance calcineurin-binding and enzymatic functions. Cyclophilin B is primarily expressed in T-lymphocytes, platelets, and metabolic tissues under normal conditions, and its expression increases in response to endoplasmic reticulum (ER) stress. Depending on the literature source, PPIB may also be discussed as Cyclophilin B and CYP-S1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endoplasmic reticulum, which can matter when signal is compared across treatments or changing cell states. Following PPIB across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePPIB is commonly interpreted in the context of immunology, inflammation, and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within endoplasmic reticulum relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PPIB. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PPIB reflect biology rather than handling. When interpreting PPIB, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PPIB trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577991045465,"sku":"F3009-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577991078233,"sku":"F3009-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577991111001,"sku":"F3009-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3009-wb.gif?v=1773600883","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ppib-antibody-sc-f3009","provider":"Absource Diagnostics","version":"1.0","type":"link"}