{"product_id":"plcgamma2-antibody-sc-f3015","title":"PLCγ2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePLCGAMMA2 is a target of interest in many antibody-based workflows. Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a crucial intracellular enzyme and a critical signaling molecule predominantly expressed in hematopoietic cells, where it mediates signaling downstream of immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors. Structurally, PLCγ2 contains multiple domains, including a split pleckstrin homology (PH) domain, Src homology 2 (SH2) and SH3 domains, and a regulatory domain that autoinhibits the catalytic site until phosphorylation relieves this inhibition. Depending on the literature source, PLCGAMMA2 may also be discussed as Hexokinase 1 and Hexokinase I.\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane, which can matter when signal is compared across treatments or changing cell states. Following PLCGAMMA2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePLCGAMMA2 is commonly interpreted in the context of cancer and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within membrane relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PLCGAMMA2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PLCGAMMA2 reflect biology rather than handling. When interpreting PLCGAMMA2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PLCGAMMA2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577999335769,"sku":"F3015-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577999368537,"sku":"F3015-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577999401305,"sku":"F3015-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3015-IF.png?v=1773600889","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/plcgamma2-antibody-sc-f3015","provider":"Absource Diagnostics","version":"1.0","type":"link"}