{"product_id":"pk11007-e1735","title":"PK11007","description":"\u003cp\u003e\u003cstrong\u003ePK11007\u003c\/strong\u003e is an inhibitor of p53 used in studies of Apoptosis and Oxidative Stress Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to caspase-associated cell-death signaling and survival decisions and redox signaling, ROS handling, and antioxidant defenses in angiogenesis, cancer, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting p53, PK11007 can be used to examine caspase-associated cell-death signaling and survival decisions and redox signaling, ROS handling, and antioxidant defenses. This context is compatible with apoptosis, viability, and caspase-readout assays and ROS, redox, and stress-response assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In angiogenesis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving p53\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Oxidative Stress Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in angiogenesis, cancer, and cell cycle models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PK11007 is appropriate when a defined chemical perturbant is needed to connect p53 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804446368089,"sku":"E1735-5MG","price":124.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804446400857,"sku":"E1735-25MG","price":372.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E1735-PK11007-chemical-structure.png?v=1776167221","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/pk11007-e1735","provider":"Absource Diagnostics","version":"1.0","type":"link"}