{"product_id":"pik3ca-antibody-sc-f0293","title":"PI3 Kinase p110α Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePI3 Kinase p110α (Phosphoinositide 3-kinase p110α, PI3K p110α), encoded by the PIK3CA gene, is a catalytic subunit of class I PI3Ks that plays a central role in cell signaling downstream of receptor tyrosine kinases (RTKs), small GTPases like Ras, and G-protein βγ subunits. Structurally, p110α consists of multiple domains, including the adaptor-binding domain (ABD), Ras-binding domain (RBD), C2 domain, helical domain, and the kinase domain, and forms a heterodimer with a regulatory subunit (e. g., p85α), which contains SH2 domains critical for recruitment to phosphotyrosine residues. Depending on the literature source, PIK3CA may also be discussed as PI3 Kinase p110alpha and Phosphatidylinositol 4.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytosol, and plasma membrane, which can matter when signal is compared across treatments or changing cell states. Following PIK3CA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePIK3CA is commonly interpreted in the context of cancer, metabolism, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytosol, and plasma membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytosol, and plasma membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PIK3CA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PIK3CA reflect biology rather than handling. When interpreting PIK3CA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PIK3CA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577438347609,"sku":"F0293-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577438380377,"sku":"F0293-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577438413145,"sku":"F0293-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0293-wb.gif?v=1773598297","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/pik3ca-antibody-sc-f0293","provider":"Absource Diagnostics","version":"1.0","type":"link"}