{"product_id":"pfi-1-pf-6405761-s1216","title":"PFI-1 (PF-6405761)","description":"\u003cp\u003e\u003cstrong\u003ePFI-1 (PF-6405761)\u003c\/strong\u003e is an inhibitor of BET used in studies of Epigenetic Regulation. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to chromatin-state control, histone modification, and transcriptional regulation in cancer and epigenetics models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting BET, PFI-1 (PF-6405761) can be used to examine chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In cancer and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving BET\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PFI-1 (PF-6405761) is appropriate when a defined chemical perturbant is needed to connect BET with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805247611225,"sku":"S1216-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805247643993,"sku":"S1216-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805247676761,"sku":"S1216-1ML\/DMSO","price":196.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/PF-06405761-chemical-structure-s1216.gif?v=1776173133","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/pfi-1-pf-6405761-s1216","provider":"Absource Diagnostics","version":"1.0","type":"link"}