{"product_id":"pf-429242-s6418","title":"PF 429242","description":"\u003cp\u003e\u003cstrong\u003ePF 429242\u003c\/strong\u003e is an inhibitor of S1P Receptors used in studies of GPCR Signaling. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting S1P Receptors, PF 429242 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving S1P Receptors\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PF 429242 is appropriate when a defined chemical perturbant is needed to connect S1P Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809377460569,"sku":"S6418-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809377493337,"sku":"S6418-25MG","price":461.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809377526105,"sku":"S6418-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/pf-429242-chemical-structure-s6418.gif?v=1776199811","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/pf-429242-s6418","provider":"Absource Diagnostics","version":"1.0","type":"link"}