{"product_id":"pf-3644022-s8224","title":"PF-3644022","description":"\u003cp\u003e\u003cstrong\u003ePF-3644022\u003c\/strong\u003e is an inhibitor of TNF-alpha used in studies of MAPK \/ ERK Signaling and NF-kB Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and inflammatory transcriptional control and stress-responsive survival signaling in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting TNF-alpha, PF-3644022 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TNF-alpha\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PF-3644022 is appropriate when a defined chemical perturbant is needed to connect TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809589895513,"sku":"S8224-5MG","price":392.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809589928281,"sku":"S8224-25MG","price":1176.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809589961049,"sku":"S8224-100MG","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809589993817,"sku":"S8224-1ML\/DMSO","price":460.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s8224-pf-3644022-chemical-structure.gif?v=1776202464","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/pf-3644022-s8224","provider":"Absource Diagnostics","version":"1.0","type":"link"}