{"product_id":"p39-antibody-sc-f1069","title":"Phospho-c-Jun (Ser63) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eP39 is a target of interest in many antibody-based workflows. Phosphorylated c-Jun (p-c-Jun), a member of the basic leucine zipper (bZIP) transcription factor family, is a critical regulator of gene expression. It features distinct domains, including N-terminal transactivation domains (TAD1 and TAD2), a δ-domain for Jun kinase (JNK) interaction, a DNA-binding domain, and a leucine zipper dimerization domain. Depending on the literature source, P39 may also be discussed as Phospho-c-Jun (Ser63) and Transcription factor Jun; Activator protein 1 (AP1); Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUN.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following P39 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eP39 is commonly interpreted in the context of cancer research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within nucleus relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for P39. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in P39 reflect biology rather than handling. When interpreting P39, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep P39 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577603367257,"sku":"F1069-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577603400025,"sku":"F1069-100UL","price":419.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577603432793,"sku":"F1069-2X100UL","price":629.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/f1069-IHC1.jpg?v=1773599249","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/p39-antibody-sc-f1069","provider":"Absource Diagnostics","version":"1.0","type":"link"}