{"product_id":"p-glycoprotein-mdr1-or-abcb1-or-cd243-antibody-ffpe-validated","title":"P-glycoprotein (MDR1 or ABCB1 or CD243) Antibody - FFPE Validated","description":"\u003ch2\u003eBiological Background\u003c\/h2\u003e\n\u003cp\u003eTo connect mechanism with measurement, this antibody lets you examine P-glycoprotein (MDR1) in pathway-driven studies. P-glycoprotein is a contact-site protein that shapes barrier properties and signaling at the cell surface. Many projects interpret this target alongside interacting partners, upstream cues, and downstream readouts.\u003c\/p\u003e\n\u003cp\u003eIn some datasets and protocols, it is referenced by the gene symbol MDR1.\u003c\/p\u003e\n\u003ch2\u003eUse in the Laboratory\u003c\/h2\u003e\n\u003cp\u003eShifts in junction organization can accompany migration, tissue morphogenesis, and altered mechanical tension. Considering complex membership and compartment shifts can clarify whether changes reflect signaling or redistribution. Blood-brain barrier models often monitor junction regulation alongside permeability-focused measurements.\u003c\/p\u003e\n\u003cp\u003eDepending on the model, researchers may ask whether signal shifts reflect altered abundance, compartment changes, or remodeling of associated complexes.\u003c\/p\u003e\n\u003cp\u003eTo keep datasets interpretable, labs often document:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eco-localization patterns with cytoskeletal elements\u003c\/li\u003e\n\u003cli\u003esubcellular redistribution at contact sites versus cytoplasm\u003c\/li\u003e\n\u003cli\u003echanges in complex assembly with scaffold or adaptor proteins\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eVersion Notes\u003c\/h2\u003e\n\u003cp\u003eBecause fixation can mask epitopes, fixed-section oriented formats aim to maintain recognition after standard deparaffinization and retrieval steps. If your study compares multiple conditions, keep acquisition and processing settings stable to avoid confounding.\u003c\/p\u003e\n\u003cp\u003eFor challenging targets, pairing P-glycoprotein measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.\u003c\/p\u003e\n\u003cp\u003eThe fixed-section option supports mechanistic reading of P-glycoprotein (MDR1) when interactions and context are the focus.\u003c\/p\u003e","brand":"BiCell Scientific","offers":[{"title":"50 µl \/ No Blocker","offer_id":58101684404569,"sku":"31705-FFPE-50UL","price":500.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 1 µg","offer_id":58101684437337,"sku":"31705-FFPE-50UL+1UG","price":569.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 10 µg","offer_id":58101684470105,"sku":"31705-FFPE-50UL+10UG","price":619.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ No Blocker","offer_id":58101684502873,"sku":"31705-FFPE-200UL","price":1110.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 1 µg","offer_id":58101684535641,"sku":"31705-FFPE-200UL+1UG","price":1179.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 10 µg","offer_id":58101684568409,"sku":"31705-FFPE-200UL+10UG","price":1229.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/mdr1-brain-pfa_6e511c48-45a4-4ab6-a932-0ce822d2f725.jpg?v=1779281053","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/p-glycoprotein-mdr1-or-abcb1-or-cd243-antibody-ffpe-validated","provider":"Absource Diagnostics","version":"1.0","type":"link"}