{"product_id":"onalespib-at13387-s1163","title":"Onalespib (AT13387)","description":"\u003cp\u003e\u003cstrong\u003eOnalespib (AT13387)\u003c\/strong\u003e is an inhibitor of HSP90 used in studies of target-focused biology. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to annotated target biology and downstream cellular responses in cancer and protein homeostasis models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HSP90, Onalespib (AT13387) can be used to examine annotated target biology and downstream cellular responses. That positioning is consistent with concentration-response inhibition and target-dependence studies and with follow-up studies that compare concentration-dependent responses across orthogonal assay formats. In cancer and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HSP90\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer and protein homeostasis models\u003c\/li\u003e\n\u003cli\u003eCombination studies with orthogonal perturbagens\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Onalespib (AT13387) is appropriate when a defined chemical perturbant is needed to connect HSP90 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805235126617,"sku":"S1163-5MG","price":265.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805235159385,"sku":"S1163-10MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805235192153,"sku":"S1163-50MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805235224921,"sku":"S1163-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805235257689,"sku":"S1163-1ML\/DMSO","price":432.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/AT13387-chemical-structure-s1163.gif?v=1776173024","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/onalespib-at13387-s1163","provider":"Absource Diagnostics","version":"1.0","type":"link"}