{"product_id":"ogt-antibody-sc-f0696","title":"OGT Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eO-linked N-acetylglucosamine transferase (OGT) is a pivotal enzyme that catalyzes the addition of O-GlcNAc, a monosaccharide, to serine and threonine residues on proteins within the cytoplasm, nucleus, and mitochondria. This post-translational modification regulates transcription, signal transduction, chromatin remodelling, and protein stability. OGT consists of tetratricopeptide repeat (TPR) domains for substrate recognition and a catalytic region, essential for glycosylation.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, cytoplasm, and membrane, which can matter when signal is compared across treatments or changing cell states. Following OGT across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eOGT is commonly interpreted in the context of metabolism, epigenetics, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for OGT. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in OGT reflect biology rather than handling. When interpreting OGT, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep OGT trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577504375129,"sku":"F0696-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577504407897,"sku":"F0696-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577504440665,"sku":"F0696-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0696-wb.gif?v=1773598809","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ogt-antibody-sc-f0696","provider":"Absource Diagnostics","version":"1.0","type":"link"}