{"product_id":"nt5e-cd73-antibody-sc-f4081","title":"NT5E\/CD73 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNT5E\/CD73, is a membrane-bound ecto-5′-nucleotidase that functions as a glycosylphosphatidylinositol (GPI)-anchored homodimer, catalyzing the largely irreversible hydrolysis of extracellular adenosine monophosphate (AMP) into adenosine and inorganic phosphate. Structurally, it comprises N-terminal Zn²⁺-binding and glycosylated domains linked to C-terminal substrate-binding domains via a flexible α-helix, enabling open-closed conformational changes during catalysis. Depending on the literature source, NT5E\/CD73 may also be discussed as NT5E\/CD73 and 5'-nucleotidase; 5'-deoxynucleotidase 2; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase 2; Thymidylate 5'-phosphatase; CD73; 5'-NT; NT5; NTE.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following NT5E\/CD73 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNT5E\/CD73 is commonly interpreted in the context of cancer, immunology, and cardiovascular research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NT5E\/CD73. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NT5E\/CD73 reflect biology rather than handling. When interpreting NT5E\/CD73, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NT5E\/CD73 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578057466201,"sku":"F4081-20UL","price":159.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578057498969,"sku":"F4081-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578057531737,"sku":"F4081-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F4081-wb.gif?v=1773601643","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/nt5e-cd73-antibody-sc-f4081","provider":"Absource Diagnostics","version":"1.0","type":"link"}