{"product_id":"nt-0527-e6630","title":"NT-0527","description":"\u003cp\u003e\u003cstrong\u003eNT-0527\u003c\/strong\u003e is an inhibitor of NLRP3 used in studies of NF-kB Signaling and Immune Signaling. In practice, this places the compound in experiments that measure inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting NLRP3, NT-0527 can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving NLRP3\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to NF-kB Signaling and Immune Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, NT-0527 is appropriate when a defined chemical perturbant is needed to connect NLRP3 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805031440729,"sku":"E6630-5MG","price":194.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805031473497,"sku":"E6630-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805031506265,"sku":"E6630-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805031539033,"sku":"E6630-1G","price":2919.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E6630-NT-0527-chemical-structure.png?v=1776170941","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/nt-0527-e6630","provider":"Absource Diagnostics","version":"1.0","type":"link"}