{"product_id":"nphs2-antibody-sc-f2765","title":"NPHS2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNPHS2 (Nephrosis 2), also known as podocin is a gene, encoding integral membrane protein belonging to the stomatin family. Structurally, it has a hairpin-like single transmembrane domain and cytoplasmic C- and N-terminal ends. It is uniquely expressed in kidney podocytes, where it localizes to the glomerular slit diaphragm, a key component of the filtration barrier. Depending on the literature source, NPHS2 may also be discussed as Podocin.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, endoplasmic reticulum, and membrane, which can matter when signal is compared across treatments or changing cell states. Following NPHS2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNPHS2 is commonly interpreted in the context of developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, endoplasmic reticulum, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, endoplasmic reticulum, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NPHS2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NPHS2 reflect biology rather than handling. When interpreting NPHS2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NPHS2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577970925913,"sku":"F2765-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577970958681,"sku":"F2765-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577970991449,"sku":"F2765-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2765-wb.gif?v=1773600676","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/nphs2-antibody-sc-f2765","provider":"Absource Diagnostics","version":"1.0","type":"link"}