{"product_id":"nmdar2b-antibody-sc-f2394","title":"Phospho-NMDAR2B (Ser1303) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNMDAR2B is a target of interest in many antibody-based workflows. The N-methyl-D-aspartate receptor (NMDAR) is a heterodimer composed of at least one NR1 subunit and one NR2A-D subunit. Various receptor isoforms with distinct functional properties and brain distributions are generated through alternative splicing of NR1 transcripts and differential expression of NR2 subunits. The NR1 subunit binds glycine as a co-agonist, while the NR2 subunit binds glutamate, the primary neurotransmitter. Depending on the literature source, NMDAR2B may also be discussed as Phospho-NMDAR2B (Ser1303).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, cytoplasm, and cytoskeleton, which can matter when signal is compared across treatments or changing cell states. Following NMDAR2B across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNMDAR2B is commonly interpreted in the context of neuroscience and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NMDAR2B. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NMDAR2B reflect biology rather than handling. When interpreting NMDAR2B, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NMDAR2B trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577933767001,"sku":"F2394-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577933799769,"sku":"F2394-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577933832537,"sku":"F2394-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2394-wb.gif?v=1773600365","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/nmdar2b-antibody-sc-f2394","provider":"Absource Diagnostics","version":"1.0","type":"link"}