{"product_id":"nicotinamide-riboside-chloride-nr-cl-s2935","title":"Nicotinamide Riboside Chloride (NR-Cl)","description":"\u003cp\u003e\u003cstrong\u003eNicotinamide Riboside Chloride (NR-Cl)\u003c\/strong\u003e is a research compound associated with Sirtuins and is relevant to studies of DNA Damage Response and Epigenetic Regulation. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation in aging, cancer, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eThe current annotation links Nicotinamide Riboside Chloride (NR-Cl) to Sirtuins, supporting target-focused studies that measure checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation without assigning a more specific primary mechanism than the dataset provides. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In aging, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Sirtuins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eMetabolite supplementation and biochemical reference studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Nicotinamide Riboside Chloride (NR-Cl) is appropriate when a defined chemical perturbant is needed to connect Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57805814137177,"sku":"S2935-25MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805814169945,"sku":"S2935-100MG","price":291.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805814202713,"sku":"S2935-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805814235481,"sku":"S2935-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/nicotinamide-riboside-chloride-chemical-structure-s2935.gif?v=1776176001","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/nicotinamide-riboside-chloride-nr-cl-s2935","provider":"Absource Diagnostics","version":"1.0","type":"link"}