{"product_id":"nbn-antibody-sc-f0868","title":"p95\/NBS1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNBN is a target of interest in many antibody-based workflows. The NBS1 protein is a key component of the MRE11\/RAD50\/NBS1 (MRN) complex, which plays a vital role in the cellular response to DNA damage and the preservation of chromosomal stability. Complete loss of NBS1 function is lethal, while hypomorphic mutations that partially impair NBS1 function are linked to Nijmegen breakage syndrome (NBS). Depending on the literature source, NBN may also be discussed as p95\/NBS1 and Nbs1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, nucleus, and telomere, which can matter when signal is compared across treatments or changing cell states. Following NBN across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNBN is commonly interpreted in the context of dna damage \/ repair and cell cycle research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, nucleus, and telomere, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, nucleus, and telomere across matched conditions\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NBN. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NBN reflect biology rather than handling. When interpreting NBN, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NBN trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577541108057,"sku":"F0868-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577541140825,"sku":"F0868-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577541173593,"sku":"F0868-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0868-IF.png?v=1773599032","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/nbn-antibody-sc-f0868","provider":"Absource Diagnostics","version":"1.0","type":"link"}