{"product_id":"mthfd2-antibody-sc-f2779","title":"MTHFD2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMethylenetetrahydrofolate dehydrogenase\/cyclohydrolase (MTHFD2) is a 37 kDa mitochondrial enzyme crucial for folate-mediated one-carbon metabolism, with bifunctional dehydrogenase and cyclohydrolase activities that produce 10-formyltetrahydrofolate for nucleotide synthesis and NADH generation. Structurally, MTHFD2 forms a homodimer and requires magnesium ions and phosphate for activity. It is highly expressed in embryonic tissues and cancers but minimally in most adult tissues.\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane, mitochondrion, and mitochondrion inner membrane, which can matter when signal is compared across treatments or changing cell states. Following MTHFD2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state. In practice, this target is often considered at the family or isoform-group level, so experimental interpretation benefits from matched controls and clear comparison logic.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eMTHFD2 is commonly interpreted in the context of cancer, metabolism, and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, mitochondrion, and mitochondrion inner membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between membrane, mitochondrion, and mitochondrion inner membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for MTHFD2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in MTHFD2 reflect biology rather than handling. When interpreting MTHFD2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep MTHFD2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577971548505,"sku":"F2779-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577971581273,"sku":"F2779-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577971614041,"sku":"F2779-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2779-IF.png?v=1773600684","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/mthfd2-antibody-sc-f2779","provider":"Absource Diagnostics","version":"1.0","type":"link"}