{"product_id":"mrp2-abcc2-antibody-sc-f3053","title":"MRP2 \/ ABCC2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMRP2 \/ ABCC2 (Multidrug resistance protein 2) is a 1545-amino acid ATP-binding cassette (ABC) transporter predominantly localized to the apical membranes of polarized epithelial cells, including hepatocytes, renal proximal tubules, enterocytes, and placental syncytiotrophoblasts. Structurally, MRP2 belongs to the “long MRPs” of the ABCC subfamily and features three membrane-spanning domains (MSD0, MSD1, MSD2) and two cytosolic nucleotide-binding domains (NBD1 and NBD2), which hydrolyze ATP to power the efflux of substrates. Depending on the literature source, MRP2 \/ ABCC2 may also be discussed as MRP2 \/ ABCC2 and ATP-binding cassette sub-family C member 2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following MRP2 \/ ABCC2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eMRP2 \/ ABCC2 is commonly interpreted in the context of metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for MRP2 \/ ABCC2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in MRP2 \/ ABCC2 reflect biology rather than handling. When interpreting MRP2 \/ ABCC2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep MRP2 \/ ABCC2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578001203545,"sku":"F3053-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578001236313,"sku":"F3053-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578001269081,"sku":"F3053-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3053-wb.gif?v=1773600915","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/mrp2-abcc2-antibody-sc-f3053","provider":"Absource Diagnostics","version":"1.0","type":"link"}