{"product_id":"mmp14-antibody-sc-f1041","title":"MMP14 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMatrix metalloproteinases (MMPs) are a class of zinc-dependent endopeptidases responsible for the degradation of nearly all extracellular matrix and basement membrane components at times of protease-mediated tissue remodeling. Among the 25 members of the matrix metalloproteinase (MMP) family, MMP14, also known as MT1-MMP, is a type I transmembrane protein that cleaves gelatin, fibronectin, and laminin. Depending on the literature source, MMP14 may also be discussed as MT1-MMP.\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane and cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following MMP14 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eMMP14 is commonly interpreted in the context of cancer and endocrinology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between membrane and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses to hormone-dependent signaling or endocrine feedback context\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for MMP14. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in MMP14 reflect biology rather than handling. When interpreting MMP14, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep MMP14 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577594945881,"sku":"F1041-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577594978649,"sku":"F1041-100UL","price":369.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577595011417,"sku":"F1041-2X100UL","price":549.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1041-IF.png?v=1773599214","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/mmp14-antibody-sc-f1041","provider":"Absource Diagnostics","version":"1.0","type":"link"}