{"product_id":"mln2238-ixazomib-s2180","title":"MLN2238 (Ixazomib)","description":"\u003cp\u003e\u003cstrong\u003eMLN2238 (Ixazomib)\u003c\/strong\u003e is an inhibitor of Proteasome used in studies of Autophagy and Protein Degradation \/ Proteasome. It is especially relevant in autophagy, cancer, and protein homeostasis models, where defined compound exposure can be linked to autophagic flux, lysosomal turnover, and stress adaptation and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Proteasome, MLN2238 (Ixazomib) can be used to examine autophagic flux, lysosomal turnover, and stress adaptation and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The protease annotation adds relevance to protease-activity, cleavage, and substrate-processing assays, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Proteasome\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Autophagy and Protein Degradation \/ Proteasome\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eProtease-activity, cleavage, and substrate-processing assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, MLN2238 (Ixazomib) is appropriate when a defined chemical perturbant is needed to connect Proteasome with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805449691481,"sku":"S2180-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805449724249,"sku":"S2180-10MG","price":314.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805449757017,"sku":"S2180-50MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805449789785,"sku":"S2180-1G","price":6869.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805449822553,"sku":"S2180-1ML\/DMSO","price":245.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/MLN2238-chemical-structure-S2180.gif?v=1776174593","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/mln2238-ixazomib-s2180","provider":"Absource Diagnostics","version":"1.0","type":"link"}