{"product_id":"mk-8776-sch-900776-s2735","title":"MK-8776 (SCH 900776)","description":"\u003cp\u003e\u003cstrong\u003eMK-8776 (SCH 900776)\u003c\/strong\u003e is an inhibitor of CHK and CDK2 and related targets used in studies of DNA Damage Response and Cell Cycle Regulation. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and checkpoint control, mitotic progression, and proliferation timing in cancer, cell cycle, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting CHK and CDK2 and related targets, MK-8776 (SCH 900776) can be used to examine checkpoint activation, DNA repair, and genome-stability control and checkpoint control, mitotic progression, and proliferation timing. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell cycle, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CHK and CDK2 and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Cell Cycle Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, MK-8776 (SCH 900776) is appropriate when a defined chemical perturbant is needed to connect CHK and CDK2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805708558681,"sku":"S2735-5MG","price":206.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805708591449,"sku":"S2735-50MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":57805708624217,"sku":"S2735-500MG","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805708656985,"sku":"S2735-1G","price":4904.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805708689753,"sku":"S2735-1ML\/DMSO","price":265.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/SCH-900776-chemical-structure-s2735.gif?v=1776175592","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/mk-8776-sch-900776-s2735","provider":"Absource Diagnostics","version":"1.0","type":"link"}