{"product_id":"me3-antibody-sc-f3349","title":"ME3 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMitochondrial Malic Enzyme 3 (ME3) is a mitochondrial NADP+-dependent enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate, producing NADPH that is crucial for maintaining cellular redox balance and supporting anabolic processes like lipid biosynthesis. ME3 is a stable homotetramer composed of four domains (A, B, C, and D), with the active site located between domains B and C, aiding substrate and cofactor binding. Depending on the literature source, ME3 may also be discussed as NADP-ME and Malic enzyme 3.\u003c\/p\u003e\u003cp\u003eReported cellular context includes mitochondrion, which can matter when signal is compared across treatments or changing cell states. Following ME3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eME3 is commonly interpreted in the context of cancer, metabolism, and oxidative stress research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans mitochondrion, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within mitochondrion relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eredox-associated shifts that may alter abundance, localization, or pathway coupling\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ME3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ME3 reflect biology rather than handling. When interpreting ME3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ME3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578016637273,"sku":"F3349-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578016670041,"sku":"F3349-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578016702809,"sku":"F3349-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3349-wb.gif?v=1773601136","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/me3-antibody-sc-f3349","provider":"Absource Diagnostics","version":"1.0","type":"link"}