{"product_id":"marcks-antibody-sc-f1259","title":"Phospho-MARCKS (Ser167\/170) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMARCKS, also known as Myristoylated Alanine-Rich C Kinase Substrate, plays a crucial role in various cellular processes like cytoskeletal remodeling, cell motility, and secretion. It primarily regulates actin dynamics, which are essential for cell movement and shape changes. Initially located on the plasma membrane, MARCKS acts as a bridge for actin filaments. Depending on the literature source, MARCKS may also be discussed as Phospho-MARCKS (Ser167\/170).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, cytoskeleton, and membrane, which can matter when signal is compared across treatments or changing cell states. Following MARCKS across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eMARCKS is commonly interpreted in the context of oxidative stress research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and cytoskeleton, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and cytoskeleton across matched conditions\u003c\/li\u003e\n\u003cli\u003eredox-associated shifts that may alter abundance, localization, or pathway coupling\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for MARCKS. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in MARCKS reflect biology rather than handling. When interpreting MARCKS, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep MARCKS trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577673490777,"sku":"F1259-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577673523545,"sku":"F1259-100UL","price":419.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577673556313,"sku":"F1259-2X100UL","price":629.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1259-IF.png?v=1773599505","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/marcks-antibody-sc-f1259","provider":"Absource Diagnostics","version":"1.0","type":"link"}